Issue 2, 2012

Facile glycosylation of dendrimers for eliciting specific cell–material interactions

Abstract

Taking advantage of the reactivity between reducing glycans and hydrazides, a facile and general approach is demonstrated to conjugate glycan epitopes to polyamidoamine (PAMAM) based dendrimers. Using HepG2 cells, it is shown that parallel studies of different glycodendrimers allowed comparison and identification of multivalent conjugates with specific cell-binding capabilities.

Graphical abstract: Facile glycosylation of dendrimers for eliciting specific cell–material interactions

Supplementary files

Article information

Article type
Communication
Submitted
08 Sep 2011
Accepted
11 Nov 2011
First published
29 Nov 2011

Polym. Chem., 2012,3, 310-313

Facile glycosylation of dendrimers for eliciting specific cell–material interactions

X. Liu, J. Liu and Y. Luo, Polym. Chem., 2012, 3, 310 DOI: 10.1039/C1PY00404B

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