Issue 6, 2012

Facially-selective thymine–thymine photodimerization in TTT triads

Abstract

Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cissyn (2 + 2) dimers formed between the central thymine and its 3′- and 5′-neighbors. Selective formation of the 3′-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.

Graphical abstract: Facially-selective thymine–thymine photodimerization in TTT triads

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr 2012
Accepted
27 Apr 2012
First published
30 Apr 2012

Photochem. Photobiol. Sci., 2012,11, 889-892

Facially-selective thymine–thymine photodimerization in TTT triads

P. P. Neelakandan, Z. Pan, M. Hariharan and F. D. Lewis, Photochem. Photobiol. Sci., 2012, 11, 889 DOI: 10.1039/C2PP25089F

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