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Issue 2, 2013
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Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation

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Abstract

An asymmetric synthesis of cyclic amino acids having piperidine and azepane core structures was realized starting from readily available glycine and alanine esters by combination of phase-transfer catalyzed asymmetric alkylation and subsequent reductive amination.

Graphical abstract: Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation

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Publication details

The article was received on 10 Sep 2012, accepted on 04 Oct 2012 and first published on 05 Oct 2012


Article type: Paper
DOI: 10.1039/C2OB26778K
Citation: Org. Biomol. Chem., 2013,11, 271-278
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    Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation

    T. Kano, T. Kumano, R. Sakamoto and K. Maruoka, Org. Biomol. Chem., 2013, 11, 271
    DOI: 10.1039/C2OB26778K

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