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Issue 45, 2012
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Rhodium-catalyzed regioselective amidation of indoles with sulfonyl azides via C–H bond activation

Jingjing Shi,a  Bing Zhou,*a  Yaxi Yanga  and  Yuanchao Li*a 
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* Corresponding authors

a Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China
E-mail: zhoubing2012@hotmail.com, ycli@mail.shcnc.ac.cn
Fax: (+) 86 21 50807288
Tel: (+) 86 21 50807288

Abstract

Direct C-2 amidation of indoles was reported using sulfonyl azides as the amino source to release N2 as the single byproduct. This reaction exhibits high functional group tolerance and regioselectivity, providing a variety of 2-amino substituted indoles in high to excellent yield. The procedure is robust, reliable, and compatible with water and air.

Graphical abstract: Rhodium-catalyzed regioselective amidation of indoles with sulfonyl azides via C–H bond activation

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Publication details

The article was received on 07 Sep 2012, accepted on 05 Oct 2012 and first published on 09 Oct 2012


Article type: Communication
DOI: 10.1039/C2OB26767E
Citation: Org. Biomol. Chem., 2012,10, 8953-8955
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    Rhodium-catalyzed regioselective amidation of indoles with sulfonyl azides via C–H bond activation

    J. Shi, B. Zhou, Y. Yang and Y. Li, Org. Biomol. Chem., 2012, 10, 8953
    DOI: 10.1039/C2OB26767E

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