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Issue 43, 2012
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Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines

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Abstract

Oligonucleotides modified with consecutive incorporations of 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridine monomers X–Z display strong thermal affinity and binding specificity toward RNA targets, due to formation of chromophore arrays in the major groove.

Graphical abstract: Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines

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Publication details

The article was received on 30 Aug 2012, accepted on 24 Sep 2012 and first published on 01 Oct 2012


Article type: Communication
DOI: 10.1039/C2OB26717A
Citation: Org. Biomol. Chem., 2012,10, 8575-8578
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    Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines

    M. Kaura, P. Kumar and P. J. Hrdlicka, Org. Biomol. Chem., 2012, 10, 8575
    DOI: 10.1039/C2OB26717A

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