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Issue 29, 2012
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A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core

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Abstract

A synthesis of the core ring structure of the fargenin/fargenone family of natural products is presented. The general strategy is based upon biosynthetic speculation and exploits a cascade reaction, which transforms a spirocyclic dienone into the core ring system via a deprotonation–oxy-Michael–Wittig olefination sequence. This study represents the first synthesis work towards this family of natural products.

Graphical abstract: A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core

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Publication details

The article was received on 06 Mar 2012, accepted on 30 May 2012 and first published on 01 Jun 2012


Article type: Paper
DOI: 10.1039/C2OB25489A
Citation: Org. Biomol. Chem., 2012,10, 5629-5635
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    A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core

    R. M. Denton and J. T. Scragg, Org. Biomol. Chem., 2012, 10, 5629
    DOI: 10.1039/C2OB25489A

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