Jump to main content
Jump to site search

Issue 40, 2012
Previous Article Next Article

Kinetics screening of the N-alkylation of organic superbases using a continuous flow microfluidic device: basicity versus nucleophilicity

Author affiliations

Abstract

We describe here the determination of the alkylation rate of a set of organic superbases by iodomethane in DMF using a microfluidic continuous flow reactor. Surprisingly, log kAlkylation follows the inverse trend of pKBH+ of the base. Mayr's equation allows a more quantitative approach. From a synthetic point of view, TMGN and BEMP are demonstrated to be the best choices.

Graphical abstract: Kinetics screening of the N-alkylation of organic superbases using a continuous flow microfluidic device: basicity versus nucleophilicity

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Jan 2012, accepted on 29 Aug 2012 and first published on 31 Aug 2012


Article type: Communication
DOI: 10.1039/C2OB25215E
Citation: Org. Biomol. Chem., 2012,10, 8059-8063
  •   Request permissions

    Kinetics screening of the N-alkylation of organic superbases using a continuous flow microfluidic device: basicity versus nucleophilicity

    A. Gholamipour-Shirazi and C. Rolando, Org. Biomol. Chem., 2012, 10, 8059
    DOI: 10.1039/C2OB25215E

Search articles by author

Spotlight

Advertisements