Issue 10, 2012
From the journal:

Organic & Biomolecular Chemistry

A highly diastereoselective three-component tandem 1,4-conjugated addition–cyclization reaction to multisubstituted pyrrolidines†

Xia Zhang,a   Jingjing Ji,a   Yingguang Zhu,a   Changcheng Jing,a   Ming Lia  and  Wenhao Hu*a  

* Corresponding authors

a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, China
E-mail: whu@chem.ecnu.edu.cn
Fax: (+86) 021-62233176

Abstract

A highly diastereoselective three-component tandem 1,4-conjugate addition–cyclization reaction of diazoacetophenones with anilines and unsaturated ketoesters was developed. The reaction provides general, easy, and highly efficient access to multisubstituted pyrrolidines in good yield with high diastereoselectivity.

Graphical abstract: A highly diastereoselective three-component tandem 1,4-conjugated addition–cyclization reaction to multisubstituted pyrrolidines

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Article information

DOI
https://doi.org/10.1039/C2OB06760A
Article type
Paper
Submitted
20 Oct 2011
Accepted
21 Dec 2011
First published
06 Feb 2012

Org. Biomol. Chem., 2012,10, 2133-2138

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A highly diastereoselective three-component tandem 1,4-conjugated addition–cyclization reaction to multisubstituted pyrrolidines

X. Zhang, J. Ji, Y. Zhu, C. Jing, M. Li and W. Hu, Org. Biomol. Chem., 2012, 10, 2133 DOI: 10.1039/C2OB06760A

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