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Issue 13, 2012
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Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach.

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Abstract

One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor–enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-β-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzymes, which highlights how different inhibitor classes can inhibit the same enzyme. This study will aid in the future development of inhibitors of not only exo-β-N-acetylhexosaminidases but also other types of glycoside hydrolases.

Graphical abstract: Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach.

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Publication details

The article was received on 26 Sep 2011, accepted on 20 Jan 2012 and first published on 27 Feb 2012


Article type: Paper
DOI: 10.1039/C2OB06636J
Citation: Org. Biomol. Chem., 2012,10, 2607-2612
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    Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach.

    T. Sumida, K. A. Stubbs, M. Ito and S. Yokoyama, Org. Biomol. Chem., 2012, 10, 2607
    DOI: 10.1039/C2OB06636J

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