Issue 8, 2012
From the journal:

Organic & Biomolecular Chemistry

Highly selective, naked-eye and fluorescent “off-on” probe for detection of histidine/histidine-rich proteins and its application in living cell imaging†

Shenyi Zhang,a   Chunmei Yang,a   Weiping Zhu,a   Bubing Zeng,a   Youjun Yang,a   Yufang Xu*a  and  Xuhong Qian*a  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy East China University of Science and Technology, Meilong Road 130, Shanghai, China
E-mail: yfxu@ecust.edu.cn, xhqian@ecust.edu.cn
Fax: (+86) 21-64252603

Abstract

A highly selective colorimetric and fluorescence enhanced probe S1 (M2@Cu) for histidine and histidine-rich proteins has been developed. In neutral aqueous ethanol solution, probe S1 can selectively detect histidine out of twenty DNA encoded amino acids by showing a color change from brownish red to light green, and with a fluorescence enhancement up to 99-fold at 537 nm, simultaneously.

Graphical abstract: Highly selective, naked-eye and fluorescent “off-on” probe for detection of histidine/histidine-rich proteins and its application in living cell imaging

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Article information

DOI
https://doi.org/10.1039/C2OB06520G
Article type
Paper
Submitted
04 Sep 2011
Accepted
28 Nov 2011
First published
11 Jan 2012

Org. Biomol. Chem., 2012,10, 1653-1658

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Highly selective, naked-eye and fluorescent “off-on” probe for detection of histidine/histidine-rich proteins and its application in living cell imaging

S. Zhang, C. Yang, W. Zhu, B. Zeng, Y. Yang, Y. Xu and X. Qian, Org. Biomol. Chem., 2012, 10, 1653 DOI: 10.1039/C2OB06520G

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