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Issue 7, 2012
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Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy

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Abstract

The fluorescence-labeled closo-dodecaborane lipid (FL-SBL) was synthesized from (S)-(+)-1,2-isopropylideneglycerol as a chiral starting material. FL-SBL was readily accumulated into the PEGylated DSPC liposomes prepared from DSPC, CH, and DSPE-PEG-OMe by the post insertion protocol. The boron concentrations and the fluorescent intensities of the FL-SBL-labeled DSPC liposomes increased with the increase of the additive FL-SBL, and the maximum emission wavelength of the liposomes appeared at 531 nm. A preliminary in vivo imaging study of tumor-bearing mice revealed that the FL-SBL-labeled DSPC liposomes were delivered to the tumor tissue but not distributed to hypoxic regions.

Graphical abstract: Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy

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Publication details

The article was received on 01 Sep 2011, accepted on 01 Nov 2011 and first published on 03 Nov 2011


Article type: Paper
DOI: 10.1039/C1OB06500A
Citation: Org. Biomol. Chem., 2012,10, 1374-1380
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    Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy

    H. Nakamura, N. Ueda, H. S. Ban, M. Ueno and S. Tachikawa, Org. Biomol. Chem., 2012, 10, 1374
    DOI: 10.1039/C1OB06500A

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