Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 17, 2012
Previous Article Next Article

Bioconjugation of luminescent silicon quantum dots to gadolinium ions for bioimaging applications

Author affiliations

Abstract

Luminescent imaging agents and MRI contrast agents are desirable components in the rational design of multifunctional nanoconstructs for biological imaging applications. Luminescent biocompatible silicon quantum dots (SiQDs) and gadolinium chelates can be applied for fluorescence microscopy and MRI, respectively. Here, we report the first synthesis of a nanocomplex incorporating SiQDs and gadolinium ions (Gd3+) for biological applications. The nanoconstruct is composed of a PEGylated micelle, with hydrophobic SiQDs in its core, covalently bound to DOTA-chelated Gd3+. Dynamic light scattering reveals a radius of 85 nm for these nanoconstructs, which is consistent with the electron microscopy results depicting radii ranging from 25 to 60 nm. Cellular uptake of the probes verified that they maintain their optical properties within the intracellular environment. The magnetic resonance relaxivity of the nanoconstruct was 2.4 mM−1 s−1 (in terms of Gd3+ concentration), calculated to be around 6000 mM−1 s−1 per nanoconstruct. These desirable optical and relaxivity properties of the newly developed probe open the door for use of SiQDs in future multimodal applications such as tumour imaging.

Graphical abstract: Bioconjugation of luminescent silicon quantum dots to gadolinium ions for bioimaging applications

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 25 Apr 2012, accepted on 01 Jul 2012 and first published on 04 Jul 2012


Article type: Paper
DOI: 10.1039/C2NR31002C
Citation: Nanoscale, 2012,4, 5483-5489
  •   Request permissions

    Bioconjugation of luminescent silicon quantum dots to gadolinium ions for bioimaging applications

    F. Erogbogbo, C. Chang, J. L. May, L. Liu, R. Kumar, W. Law, H. Ding, K. T. Yong, I. Roy, M. Sheshadri, M. T. Swihart and P. N. Prasad, Nanoscale, 2012, 4, 5483
    DOI: 10.1039/C2NR31002C

Search articles by author