Issue 11, 2012
From the journal:

New Journal of Chemistry

A T1, T2 magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium–europium oxide nanoparticles†

Wenlong Xu,a   Ja Young Park,a   Krishna Kattel,a   Badrul Alam Bony,a   Woo Choul Heo,a   Seonguk Jin,b   Jang Woo Park,b   Yongmin Chang,*b   Ji Yeon Do,c   Kwon Seok Chae,*c   Tae Jeong Kim,d   Ji Ae Park,e   Young Woo Kwaka  and  Gang Ho Lee*a  

* Corresponding authors

a Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 702-701, South Korea
E-mail: ghlee@mail.knu.ac.kr
Fax: +82-53-950-6330
Tel: +82-53-950-5340

b Department of Molecular Medicine and Medical & Biological Engineering, School of Medicine, Kyungpook National University and Hospital, Taegu 702-701, South Korea
E-mail: ychang@knu.ac.kr

c Department of Biology Education, Teachers' College, Kyungpook National University, Taegu 702-701, South Korea
E-mail: kschae@knu.ac.kr

d Department of Applied Chemistry, College of Engineering, Kyungpook National University, Taegu 702-701, South Korea

e Laboratory of Nuclear Medicine Research, Molecular Imaging Research Center, Korea Institute of Radiological Medical Science, Nowon-gil 75, Seoul 139-706, South Korea

Abstract

Multiple molecular imaging is a challenging subject. Water-soluble and biocompatible lactobionic acid coated ultrasmall mixed gadolinium–europium oxide nanoparticles with an average particle diameter of 1.75 nm and an average hydrodynamic diameter of 4.16 nm were synthesized and applied for T1, T2 MRI-FI in vitro and in vivo. They had r1 and r2 values of 11.9 and 38.7 s−1 mM−1, respectively, and showed clear dose-dependent contrast changes in both R1 and R2 map images. In addition, they showed both positive and negative contrast enhancements in 3 tesla T1 and T2 MR images in a mouse, respectively, and fluorescent confocal images in both DU145 cells and C. elegans (a small nematode). This study demonstrates the T1, T2 MRI-FI multi-functionality of lactobionic acid coated mixed gadolinium–europium oxide nanoparticles.

Graphical abstract: A T1, T2 magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium–europium oxide nanoparticles

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Article information

DOI
https://doi.org/10.1039/C2NJ40149E
Article type
Paper
Submitted
29 Feb 2012
Accepted
26 Aug 2012
First published
29 Aug 2012

New J. Chem., 2012,36, 2361-2367

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A T1, T2 magnetic resonance imaging (MRI)-fluorescent imaging (FI) by using ultrasmall mixed gadolinium–europium oxide nanoparticles

W. Xu, J. Y. Park, K. Kattel, B. A. Bony, W. C. Heo, S. Jin, J. W. Park, Y. Chang, J. Y. Do, K. S. Chae, T. J. Kim, J. A. Park, Y. W. Kwak and G. H. Lee, New J. Chem., 2012, 36, 2361 DOI: 10.1039/C2NJ40149E

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