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Issue 2, 2012
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Stimuli sensitive amphiphilic dendrimers

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In the past decade, there has been an increasing interest in supramolecular systems that can undergo physical or chemical transformations upon encountering a specific stimulus. Micelle-forming amphiphilic systems based on polymers and dendrimers are particularly preferred over small molecule amphiphiles, due to their ability to sequester and release a vast library of hydrophobic guest molecules at micromolar polymer or dendrimer concentrations. Here we review a relatively underexplored, yet rapidly advancing, field of amphiphilic systems based on a dendritic architecture that exhibit stimuli sensitive behaviour. In particular, we will be focusing on stimuli such as temperature, pH, enzymatic and non-enzymatic proteins. These stimuli-responsive systems offer a unique opportunity in the field of drug delivery and sensing.

Graphical abstract: Stimuli sensitive amphiphilic dendrimers

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Publication details

The article was received on 12 Oct 2011, accepted on 19 Dec 2011 and first published on 16 Jan 2012

Article type: Perspective
DOI: 10.1039/C2NJ20879B
Citation: New J. Chem., 2012,36, 340-349
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    Stimuli sensitive amphiphilic dendrimers

    R. R. Ramireddy, K. R. Raghupathi, D. A. Torres and S. Thayumanavan, New J. Chem., 2012, 36, 340
    DOI: 10.1039/C2NJ20879B

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