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Issue 2, 2013
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Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

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Abstract

Novel guanidinium and urea derivatives of 1-deoxynojirimycin were prepared using a concise synthetic protocol and tested against a panel of glycosidases for their inhibitory properties. Potent and selective inhibition was observed with both classes of compounds. Further investigation involving an expanded series of NG-substituted guanidinium deoxynojirimycin analogues revealed distinct inhibitory profiles in the inhibition of the glycosidases tested.

Graphical abstract: Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

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Publication details

The article was received on 10 Nov 2012, accepted on 29 Nov 2012 and first published on 30 Nov 2012


Article type: Concise Article
DOI: 10.1039/C2MD20343J
Citation: Med. Chem. Commun., 2013,4, 387-393
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    Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

    R. Kooij, H. M. Branderhorst, S. Bonte, S. Wieclawska, N. I. Martin and R. J. Pieters, Med. Chem. Commun., 2013, 4, 387
    DOI: 10.1039/C2MD20343J

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