Issue 10, 2012
From the journal:

MedChemComm

Rational design of small modified peptides as ACE inhibitors†

Daniel G. Silva,a   Matheus P. Freitas,*a   Elaine F. F. da Cunha,a   Teodorico C. Ramalhoa  and  Cleiton A. Nunesb  

* Corresponding authors

a Department of Chemistry, Federal University of Lavras, Lavras, MG, Brazil
E-mail: matheus@dqi.ufla.br
Fax: +55 35 3829 1271
Tel: +55 35 3829 1891

b Department of Food Science, Federal University of Lavras, Lavras, MG, Brazil

Abstract

Computer-assisted techniques and the strategy of combining chemical substructures were used to derive small modified peptides as potent angiotensin-converting enzyme (ACE) inhibitors. In addition to high potency, some of the predicted compounds are also shown to exhibit satisfactory pharmacokinetic parameters.

Graphical abstract: Rational design of small modified peptides as ACE inhibitors

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Article information

DOI
https://doi.org/10.1039/C2MD20214J
Article type
Concise Article
Submitted
25 Apr 2012
Accepted
29 Aug 2012
First published
31 Aug 2012

Med. Chem. Commun., 2012,3, 1290-1293

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Rational design of small modified peptides as ACE inhibitors

D. G. Silva, M. P. Freitas, E. F. F. da Cunha, T. C. Ramalho and C. A. Nunes, Med. Chem. Commun., 2012, 3, 1290 DOI: 10.1039/C2MD20214J

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