Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance†
Abstract
A series of
a
Department of Chemistry, University of California Santa Cruz, California, USA
E-mail:
slokey@ucsc.edu
b
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
E-mail:
Matt.Jacobson@ucsf.edu
Tel: +1 415-514-9811
c Pharmacokinetics and Drug Metabolism, Pfizer Inc, Groton, Connecticut, USA
d Worldwide Medicinal Chemistry, Pfizer Inc, Groton, Connecticut, USA
e
Worldwide Medicinal Chemistry, Pfizer Inc, Cambridge, Massachusetts, USA
E-mail:
alan.m.mathiowetz@pfizer.com
Tel: +1 617-551-3514
A series of
A. C. Rand, S. S. F. Leung, H. Eng, C. J. Rotter, R. Sharma, A. S. Kalgutkar, Y. Zhang, M. V. Varma, K. A. Farley, B. Khunte, C. Limberakis, D. A. Price, S. Liras, A. M. Mathiowetz, M. P. Jacobson and R. S. Lokey, Med. Chem. Commun., 2012, 3, 1282 DOI: 10.1039/C2MD20203D
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