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Issue 1, 2013
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Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

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Abstract

Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.

Graphical abstract: Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 16 Jul 2012, accepted on 29 Aug 2012 and first published on 31 Aug 2012


Article type: Concise Article
DOI: 10.1039/C2MD20196H
Citation: Med. Chem. Commun., 2013,4, 175-179
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    Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

    H. Ganin, J. Rayo, N. Amara, N. Levy, P. Krief and M. M. Meijler, Med. Chem. Commun., 2013, 4, 175
    DOI: 10.1039/C2MD20196H

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