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Issue 11, 2012
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Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

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Abstract

New YC-1 derivatives were synthesized and evaluated with HIF-1 transcriptional activity, and a potent derivative shows activity in vivo. Furthermore, for the mechanistic study of the YC-1 derivative, we evaluate the antiproliferative activity against 39 human cancer cell lines and the localization of active probes in cells.

Graphical abstract: Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

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Publication details

The article was received on 25 May 2012, accepted on 20 Sep 2012 and first published on 21 Sep 2012


Article type: Concise Article
DOI: 10.1039/C2MD20134H
Citation: Med. Chem. Commun., 2012,3, 1455-1461
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    Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

    A. Takeuchi, M. Hori, S. Sato, H. S. Ban, T. Kuchimaru, S. Kizaka-Kondoh, T. Yamori and H. Nakamura, Med. Chem. Commun., 2012, 3, 1455
    DOI: 10.1039/C2MD20134H

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