Issue 5, 2012

Oxadiazole isomers: all bioisosteres are not created equal

Abstract

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

Graphical abstract: Oxadiazole isomers: all bioisosteres are not created equal

Supplementary files

Article information

Article type
Concise Article
Submitted
22 Feb 2012
Accepted
15 Mar 2012
First published
16 Mar 2012

Med. Chem. Commun., 2012,3, 600-604

Oxadiazole isomers: all bioisosteres are not created equal

K. Goldberg, S. Groombridge, J. Hudson, A. G. Leach, P. A. MacFaul, A. Pickup, R. Poultney, J. S. Scott, P. H. Svensson and J. Sweeney, Med. Chem. Commun., 2012, 3, 600 DOI: 10.1039/C2MD20054F

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