Issue 8, 2012
From the journal:

MedChemComm

Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis†

Spencer C. Peck,ab   Seung Young Kim,b   Bradley S. Evansb  and  Wilfred A. van der Donk*ab  

* Corresponding authors

a Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, IL, USA
E-mail: vddonk@illinois.edu
Fax: +1 217 244 8533
Tel: +1 217 244 5360

b Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL, USA

Abstract

Reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate is a common step in the biosynthesis of phosphonate natural products. The facial selectivity of hydride transfer from NADPH to phosphonoacetaldehyde was determined in this study in an effort to interrogate the biosynthetic pathway towards fosfomycin.

Graphical abstract: Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis

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Article information

DOI
https://doi.org/10.1039/C2MD20009K
Article type
Concise Article
Submitted
19 Jan 2012
Accepted
13 Feb 2012
First published
29 Feb 2012

Med. Chem. Commun., 2012,3, 967-970

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Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis

S. C. Peck, S. Y. Kim, B. S. Evans and W. A. van der Donk, Med. Chem. Commun., 2012, 3, 967 DOI: 10.1039/C2MD20009K

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