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Issue 21, 2012
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Microfluidic diagnostic tool for the developing world: contactless impedance flow cytometry

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Abstract

In this work, we demonstrate a novel and cost-effective approach to implement a disposable microfluidic contactless impedance cytometer. Conventional methods for single cell impedance cytometry use microfabricated electrodes in direct contact with the buffer to measure changes of its electrical impedance when cells pass through the applied electric field. However, this approach requires expensive microfabrication of electrodes, and also, the fabricated electrodes cannot be reused without thorough and time-consuming cleaning process. Here, we introduce a novel approach to allow for single cell impedance cytometry using electrodes that can be reused, without the need for microfabrication of the electrodes. This disposable device can be potentially inserted onto a printed circuit board (PCB) which has a non-disposable, yet inexpensive, electronic reading apparatus. This significantly reduces the manufacturing costs, making it suitable for low resource settings, such as point-of-care testing in the developing countries.

Graphical abstract: Microfluidic diagnostic tool for the developing world: contactless impedance flow cytometry

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Publication details

The article was received on 05 Jul 2012, accepted on 19 Aug 2012 and first published on 21 Aug 2012


Article type: Paper
DOI: 10.1039/C2LC40759K
Citation: Lab Chip, 2012,12, 4499-4507
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    Microfluidic diagnostic tool for the developing world: contactless impedance flow cytometry

    S. Emaminejad, M. Javanmard, R. W. Dutton and R. W. Davis, Lab Chip, 2012, 12, 4499
    DOI: 10.1039/C2LC40759K

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