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Issue 19, 2012
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Microfluidic sensing devices employing in situ-formed liquid crystal thin film for detection of biochemical interactions

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Abstract

Although biochemical sensing using liquid crystals (LC) has been demonstrated, relatively little attention has been paid towards the fabrication of in situ-formed LC sensing devices. Herein, we demonstrate a highly reproducible method to create uniform LC thin film on treated substrates, as needed, for LC sensing. We use shear forces generated by the laminar flow of aqueous liquid within a microfluidic channel to create LC thin films stabilized within microfabricated structures. The orientational response of the LC thin films to targeted analytes in aqueous phases was transduced and amplified by the optical birefringence of the LC thin films. The biochemical sensing capability of our sensing devices was demonstrated through experiments employing two chemical systems: dodecyl trimethylammonium bromide (DTAB) dissolved in an aqueous solution, and the hydrolysis of phospholipids by the enzyme phospholipase A2 (PLA2).

Graphical abstract: Microfluidic sensing devices employing in situ-formed liquid crystal thin film for detection of biochemical interactions

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Publication details

The article was received on 30 Apr 2012, accepted on 18 Jun 2012 and first published on 21 Jun 2012


Article type: Paper
DOI: 10.1039/C2LC40462A
Citation: Lab Chip, 2012,12, 3746-3753
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    Microfluidic sensing devices employing in situ-formed liquid crystal thin film for detection of biochemical interactions

    Y. Liu, D. Cheng, I. Lin, N. L. Abbott and H. Jiang, Lab Chip, 2012, 12, 3746
    DOI: 10.1039/C2LC40462A

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