Issue 11, 2012
From the journal:

Lab on a Chip

Contactless conductivity biosensor in microchip containing folic acid as bioreceptor†‡

Renato S. Lima,ab   Maria H. O. Piazzetta,c   Angelo L. Gobbi,c   Ubirajara P. Rodrigues-Filho,a   Pedro A. P. Nascente,d   Wendell K. T. Coltrobe  and  Emanuel Carrilho*ab  

* Corresponding authors

a Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil
E-mail: emanuel@iqsc.usp.br
Fax: +55 (16) 3373 9975
Tel: +55 (16) 3373 9441

b Instituto Nacional de Ciência e Tecnologia de Bioanalítica, Campinas, SP, Brazil

c Laboratório Nacional de Nanotecnologia, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, SP, Brazil

d Departamento de Engenharia de Materiais, Universidade Federal de São Carlos, São Carlos, SP, Brazil

e Instituto de Química, Universidade Federal de Goiás, GO, Goiânia, Brazil

Abstract

We report a glass/PDMS-based microfluidic biosensor that integrates contactless conductivity transduction and folic acid, a target for tumor biomarker, as a bioreceptor. The device presents relevant advantages such as direct determination—dismiss the use of redox mediators as in faradaic electrochemical techniques—and the absence of the known drawbacks related to the electrode-solution interface. Characterizations of the functionalization processes and chemical sensor are described in this communication.

Graphical abstract: Contactless conductivity biosensor in microchip containing folic acid as bioreceptor

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Article information

DOI
https://doi.org/10.1039/C2LC40157F
Article type
Communication
Submitted
13 Feb 2012
Accepted
17 Apr 2012
First published
18 Apr 2012

Lab Chip, 2012,12, 1963-1966

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Contactless conductivity biosensor in microchip containing folic acid as bioreceptor

R. S. Lima, M. H. O. Piazzetta, A. L. Gobbi, U. P. Rodrigues-Filho, P. A. P. Nascente, W. K. T. Coltro and E. Carrilho, Lab Chip, 2012, 12, 1963 DOI: 10.1039/C2LC40157F

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