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Issue 12, 2012
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Microengineered physiological biomimicry: Organs-on-Chips

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Abstract

Microscale engineering technologies provide unprecedented opportunities to create cell culture microenvironments that go beyond current three-dimensional in vitro models by recapitulating the critical tissue–tissue interfaces, spatiotemporal chemical gradients, and dynamic mechanical microenvironments of living organs. Here we review recent advances in this field made over the past two years that are focused on the development of ‘Organs-on-Chips’ in which living cells are cultured within microfluidic devices that have been microengineered to reconstitute tissue arrangements observed in living organs in order to study physiology in an organ-specific context and to develop specialized in vitro disease models. We discuss the potential of organs-on-chips as alternatives to conventional cell culture models and animal testing for pharmaceutical and toxicology applications. We also explore challenges that lie ahead if this field is to fulfil its promise to transform the future of drug development and chemical safety testing.

Graphical abstract: Microengineered physiological biomimicry: Organs-on-Chips

  • This article is part of the themed collection: Focus on USA
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Publication details

The article was received on 23 Jan 2012, accepted on 05 Apr 2012 and first published on 03 May 2012


Article type: Frontier
DOI: 10.1039/C2LC40089H
Citation: Lab Chip, 2012,12, 2156-2164
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    Microengineered physiological biomimicry: Organs-on-Chips

    D. Huh, Y. Torisawa, G. A. Hamilton, H. J. Kim and D. E. Ingber, Lab Chip, 2012, 12, 2156
    DOI: 10.1039/C2LC40089H

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