Jump to main content
Jump to site search

Issue 48, 2012
Previous Article Next Article

Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups

Author affiliations

Abstract

Polymer nanoparticles (PNPs) possessing a high density of drug payload have been successfully stabilized against aggregation in biological buffers after amine modification, which renders these PNPs positively charged. The resulting charge-stabilized PNPs retain their original narrow particle size distributions and well-defined spherical morphologies. This stabilization allows these PNPs to have an improved anti-proliferative effect on MDA-MB-231-Br human breast cancer cells compared to non-functionalized PNPs. As a non-cytotoxic control, similar surface-modified PNPs containing cholesterol in place of doxorubicin did not inhibit cell proliferation, indicating that the induced cytotoxic response was solely due to the doxorubicin release from the PNPs.

Graphical abstract: Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Aug 2012, accepted on 29 Oct 2012 and first published on 12 Nov 2012


Article type: Paper
DOI: 10.1039/C2JM35420A
Citation: J. Mater. Chem., 2012,22, 25463-25470
  •   Request permissions

    Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups

    S. A. Krovi, E. P. Swindell, T. V. O'Halloran and S. T. Nguyen, J. Mater. Chem., 2012, 22, 25463
    DOI: 10.1039/C2JM35420A

Search articles by author

Spotlight

Advertisements