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Issue 37, 2012
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The protein resistance of silicones prepared with a PEO-silane amphiphile

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Abstract

Silicone coatings with improved resistance to plasma proteins were prepared by incorporating a PEO-silane amphiphile: α-(EtO)3Si-(CH2)2-oligodimethylsiloxane13-block-poly(ethylene oxide)8-OCH3. The oligodimethylsiloxane tether imparts amphiphilicity and molecular mobility to the chain thereby enhancing protein resistance. Using a medical grade, silica-filled acetoxy-cure silicone, the PEO-silane amphiphile was introduced at varying levels (0, 1, 5, 10, 15 and 20 wt%) and films prepared via solvent-casting. Increased PEO-silane amphiphile content led to increased surface hydrophilicity and improved resistance to bovine serum albumin (BSA) and human fibrinogen (HF). When maintained in air, the surfaces of the coatings did not display hydrophobic recovery.

Graphical abstract: The protein resistance of silicones prepared with a PEO-silane amphiphile

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Publication details

The article was received on 14 Apr 2012, accepted on 12 Jul 2012 and first published on 13 Jul 2012


Article type: Paper
DOI: 10.1039/C2JM32322B
Citation: J. Mater. Chem., 2012,22, 19540-19546
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    The protein resistance of silicones prepared with a PEO-silane amphiphile

    M. L. Hawkins and M. A. Grunlan, J. Mater. Chem., 2012, 22, 19540
    DOI: 10.1039/C2JM32322B

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