Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 9, 2012
Previous Article Next Article

Control of stem cell fate and function by engineering physical microenvironments

Author affiliations

Abstract

The phenotypic expression and function of stem cells are regulated by their integrated response to variable microenvironmental cues, including growth factors and cytokines, matrix-mediated signals, and cell–cell interactions. Recently, growing evidence suggests that matrix-mediated signals include mechanical stimuli such as strain, shear stress, substrate rigidity and topography, and these stimuli have a more profound impact on stem cell phenotypes than had previously been recognized, e.g. self-renewal and differentiation through the control of gene transcription and signaling pathways. Using a variety of cell culture models enabled by micro and nanoscale technologies, we are beginning to systematically and quantitatively investigate the integrated response of cells to combinations of relevant mechanobiological stimuli. This paper reviews recent advances in engineering physical stimuli for stem cell mechanobiology and discusses how micro- and nanoscale engineered platforms can be used to control stem cell niche environments and regulate stem cell fate and function.

Graphical abstract: Control of stem cell fate and function by engineering physical microenvironments

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 02 Dec 2011, accepted on 05 Jul 2012 and first published on 25 Jul 2012


Article type: Review Article
DOI: 10.1039/C2IB20080E
Citation: Integr. Biol., 2012,4, 1008-1018
  •   Request permissions

    Control of stem cell fate and function by engineering physical microenvironments

    Kshitiz, J. Park, P. Kim, W. Helen, A. J. Engler, A. Levchenko and D. Kim, Integr. Biol., 2012, 4, 1008
    DOI: 10.1039/C2IB20080E

Search articles by author