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Issue 11, 2012
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A convenient guide to help select replacement solvents for dichloromethane in chromatography

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Abstract

One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of “drug-like” compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experimentally-derived solvent selection guide to aid chemists in choosing greener solvents for chromatographic purification, with a particular focus on reducing dichloromethane usage.

Graphical abstract: A convenient guide to help select replacement solvents for dichloromethane in chromatography

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Publication details

The article was received on 10 Jul 2012, accepted on 20 Aug 2012 and first published on 20 Aug 2012


Article type: Paper
DOI: 10.1039/C2GC36064K
Citation: Green Chem., 2012,14, 3020-3025
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    A convenient guide to help select replacement solvents for dichloromethane in chromatography

    J. P. Taygerly, L. M. Miller, A. Yee and E. A. Peterson, Green Chem., 2012, 14, 3020
    DOI: 10.1039/C2GC36064K

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