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Volume 161, 2013
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Tuning the aggregation behaviour of single-chain bolaphospholipids in aqueous suspension: from nanoparticles to nanofibres to lamellar phases

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Abstract

The aggregation behaviour in aqueous suspensions of symmetrical bipolar phospholipids (bolalipids) composed of one long alkyl chain and two polar headgroups were studied as a function of their chemical structure, i.e. the length of their chain, the modification of the chain by introduction of hetero-atoms, triple bonds, or phenyl rings, and the size of the headgroups. Three types of aggregate structures are formed by these bolalipids, namely helical nanofibres, micelle-like aggregates and lamellar sheets. The type of aggregate formed depends not only on the chemical structure, particularly the ratio of the cross-sectional area of the headgroup and the chain, but also on the presence of attractive interactions via hydrogen bonds or repulsive electrostatic interactions between the headgroups.

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Publication details

The article was received on 07 May 2012, accepted on 07 Jun 2012 and first published on 11 Jun 2012


Article type: Paper
DOI: 10.1039/C2FD20102J
Citation: Faraday Discuss., 2013,161, 193-213
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    Tuning the aggregation behaviour of single-chain bolaphospholipids in aqueous suspension: from nanoparticles to nanofibres to lamellar phases

    A. Blume, S. Drescher, A. Meister, G. Graf and B. Dobner, Faraday Discuss., 2013, 161, 193
    DOI: 10.1039/C2FD20102J

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