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Issue 35, 2012
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A new metallostar complex based on an aluminum(III) 8-hydroxyquinoline core as a potential bimodal contrast agent

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A ditopic DTPA monoamide derivative containing an 8-hydroxyquinoline moiety was synthesized and the corresponding gadolinium(III) complex ([Gd(H5)(H2O)]) was prepared. After adding aluminum(III), the 8-hydroxyquinoline part self-assembled into a heteropolymetallic triscomplex [(Gd5)3Al(H2O)3]3−. The magnetic and optical properties of this metallostar compound were investigated in order to classify it as a potential in vitro bimodal contrast agent. The proton nuclear magnetic relaxation dispersion measurements indicated that the relaxivity r1 of [Gd(H5)(H2O)] and [(Gd5)3Al(H2O)3]3− at 20 MHz and 310 K equaled 6.17 s−1 mM−1 and 10.9 s−1 mM−1 per Gd(III) ion respectively. This corresponds to a relaxivity value of 32.7 s−1 mM−1 for the supramolecular complex containing three Gd(III) ions. The high relaxivity value is prominently caused by an increase of the rotational tumbling time τR by a factor of 2.7 and 5.5 respectively, in comparison with the commercially used MRI contrast agent Gd(III)–DTPA (Magnevist®). Furthermore, upon UV irradiation, [(Gd5)3Al(H2O)3]3− exposes green broad-band emission with a maximum at 543 nm. Regarding the high relaxivity and the photophysical properties of the [(Gd5)3Al(H2O)3]3− metallostar compound, it can be considered as a lead compound for in vitro bimodal applications.

Graphical abstract: A new metallostar complex based on an aluminum(iii) 8-hydroxyquinoline core as a potential bimodal contrast agent

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Publication details

The article was received on 16 Mar 2012, accepted on 28 Jun 2012 and first published on 25 Jul 2012

Article type: Paper
DOI: 10.1039/C2DT30605K
Citation: Dalton Trans., 2012,41, 10549-10556
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    A new metallostar complex based on an aluminum(III) 8-hydroxyquinoline core as a potential bimodal contrast agent

    E. Debroye, G. Dehaen, S. V. Eliseeva, S. Laurent, L. Vander Elst, R. N. Muller, K. Binnemans and T. N. Parac-Vogt, Dalton Trans., 2012, 41, 10549
    DOI: 10.1039/C2DT30605K

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