Issue 1, 2012
From the journal:

Dalton Transactions

Studying the interactions of a platinum(ii) 9-aminoacridine complex with proteins and oligonucleotides by ESI-TOF MS†

Katia G. Samper,a   Consuelo Vicente,b   Venancio Rodríguez,b   Sílvia Atrian,c   Natalia Cutillas,b   Mercè Capdevila,a   José Ruizb  and  Òscar Palacios*a  

* Corresponding authors

a Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, 08193-Cerdanyola del Vallès, Barcelona, Spain
E-mail: Oscar.Palacios@uab.cat
Fax: +34 935813101
Tel: +34 935814532

b Departamento de Química Inorgánica, Universidad de Murcia, Murcia, Spain
E-mail: jruiz@um.es
Fax: +34 868 884148
Tel: +34 868 887455

c Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain

Abstract

The interaction of a novel Pt complex, [Pt(dmba)(N9-9AA)(PPh3)]+1 (dmba = N,N-dimethylbenzylamine-κN,κC; 9AA = 9-aminoacridine), which exhibits anti-tumor activity, with certain key proteins has been monitored by ESI-MS. Also, the interaction of 1 with a designed double-stranded oligonucleotide containing the GG motif has been followed by mass spectrometry as well as by fluorimetry. The results obtained show the low interaction of 1 with the considered proteins and the absence of covalent interaction with the oligonucleotides, but the fluorimetric data confirm the π–π interaction of 1 with the double-stranded DNA, which is probably the reason of the previously reported activity of 1 in several tumor cell lines.

Graphical abstract: Studying the interactions of a platinum(ii) 9-aminoacridine complex with proteins and oligonucleotides by ESI-TOF MS

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1DT11506E
Article type
Paper
Submitted
09 Aug 2011
Accepted
13 Oct 2011
First published
17 Nov 2011

Dalton Trans., 2012,41, 300-306

Permissions

Request permissions

Studying the interactions of a platinum(II) 9-aminoacridine complex with proteins and oligonucleotides by ESI-TOF MS

K. G. Samper, C. Vicente, V. Rodríguez, S. Atrian, N. Cutillas, M. Capdevila, J. Ruiz and Ò. Palacios, Dalton Trans., 2012, 41, 300 DOI: 10.1039/C1DT11506E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements