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Issue 9, 2012
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Functionalized mesoporous silica materials for controlled drug delivery

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Abstract

In the past decade, non-invasive and biocompatible mesoporous silica materials as efficient drug delivery systems have attracted special attention. Great progress in structure control and functionalization (magnetism and luminescence) design has been achieved for biotechnological and biomedical applications. This review highlights the most recent research progress on silica-based controlled drug delivery systems, including: (i) pure mesoporous silica sustained-release systems, (ii) magnetism and/or luminescence functionalized mesoporous silica systems which integrate targeting and tracking abilities of drug molecules, and (iii) stimuli-responsive controlled release systems which are able to respond to environmental changes, such as pH, redox potential, temperature, photoirradiation, and biomolecules. Although encouraging and potential developments have been achieved, design and mass production of novel multifunctional carriers, some practical biological application, such as biodistribution, the acute and chronic toxicities, long-term stability, circulation properties and targeting efficacy in vivo are still challenging.

Graphical abstract: Functionalized mesoporous silica materials for controlled drug delivery

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Publication details

The article was received on 11 Nov 2011 and first published on 22 Mar 2012


Article type: Critical Review
DOI: 10.1039/C2CS15308D
Citation: Chem. Soc. Rev., 2012,41, 3679-3698
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    Functionalized mesoporous silica materials for controlled drug delivery

    P. Yang, S. Gai and J. Lin, Chem. Soc. Rev., 2012, 41, 3679
    DOI: 10.1039/C2CS15308D

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