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Issue 9, 2012
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C–C, C–O and C–N bond formation via rhodium(III)-catalyzed oxidative C–H activation

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Abstract

Rhodium(III)-catalyzed direct functionalization of C–H bonds under oxidative conditions leading to C–C, C–N, and C–O bond formation is reviewed. Various arene substrates bearing nitrogen and oxygen directing groups are covered in their coupling with unsaturated partners such as alkenes and alkynes. The facile construction of C–E (E = C, N, S, or O) bonds makes Rh(III) catalysis an attractive step-economic approach to value-added molecules from readily available starting materials. Comparisons and contrasts between rhodium(III) and palladium(II)-catalyzed oxidative coupling are made. The remarkable diversity of structures accessible is demonstrated with various recent examples, with a proposed mechanism for each transformation being briefly summarized (critical review, 138 references).

Graphical abstract: C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation

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Publication details

The article was received on 13 Oct 2011, published on 29 Feb 2012 and first published online on 29 Feb 2012


Article type: Critical Review
DOI: 10.1039/C2CS15281A
Citation: Chem. Soc. Rev., 2012,41, 3651-3678
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    C–C, C–O and C–N bond formation via rhodium(III)-catalyzed oxidative C–H activation

    G. Song, F. Wang and X. Li, Chem. Soc. Rev., 2012, 41, 3651
    DOI: 10.1039/C2CS15281A

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