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Issue 1, 2012
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Mechanochemistry: opportunities for new and cleaner synthesis

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Abstract

The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).

Graphical abstract: Mechanochemistry: opportunities for new and cleaner synthesis

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Publication details

The article was received on 24 Jun 2011 and first published on 05 Sep 2011


Article type: Critical Review
DOI: 10.1039/C1CS15171A
Citation: Chem. Soc. Rev., 2012,41, 413-447
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    Mechanochemistry: opportunities for new and cleaner synthesis

    S. L. James, C. J. Adams, C. Bolm, D. Braga, P. Collier, T. Friščić, F. Grepioni, K. D. M. Harris, G. Hyett, W. Jones, A. Krebs, J. Mack, L. Maini, A. G. Orpen, I. P. Parkin, W. C. Shearouse, J. W. Steed and D. C. Waddell, Chem. Soc. Rev., 2012, 41, 413
    DOI: 10.1039/C1CS15171A

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