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Issue 1, 2012
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Applications of vectorized gold nanoparticles to the diagnosis and therapy of cancer

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Abstract

This critical review focuses on the anti-cancer fight using gold nanoparticles (AuNPs) functionalized with chemotherapeutic drugs in so-called “complexes” (supramolecular assemblies) and “conjugates” (covalent assemblies) as vectors. There is a considerable body of recent literature on various tumor-imaging techniques using the surface plasmon band (SPB) and the “passive” and “active” vectorization of anti-cancer drugs. This article reviews the main concepts and the most recent literature data with emphasis on AuNP preparation, cytotoxicities and use in selective targeting of cancer cells with over-expressed receptors for diagnosis and therapy (108 references).

Graphical abstract: Applications of vectorized gold nanoparticles to the diagnosis and therapy of cancer

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Publication details

The article was received on 28 Mar 2011 and first published on 22 Jul 2011


Article type: Critical Review
DOI: 10.1039/C1CS15080D
Citation: Chem. Soc. Rev., 2012,41, 242-257
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    Applications of vectorized gold nanoparticles to the diagnosis and therapy of cancer

    A. Llevot and D. Astruc, Chem. Soc. Rev., 2012, 41, 242
    DOI: 10.1039/C1CS15080D

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