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Novartis-MIT Center for Continuous Manufacturing and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E19-502b, Cambridge, United States
CrystEngComm, 2012,14, 2386-2388
DOI:
10.1039/C1CE06358H
Received
13 Oct 2011,
Accepted
09 Nov 2011
First published online
16 Nov 2011
The potential use of selective co-crystal formation as a means to remove an impurity from a solution is demonstrated using ibuprofen and ketoprofen as a model system. A strategy for selecting the optimal co-former, co-former concentration, and the solvent for the separation process is discussed.
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