Issue 2, 2012
From the journal:

CrystEngComm

A cocrystal is the key intermediates for the production of a new polymorph of Vorinostat†

Cristina Puigjaner,*a   Rafael Barbas,a   Anna Portell,a   Ismael Valverde,c   Xavier Vila,c   Xavier Alcobé,b   Mercè Font-Bardiab  and  Rafel Prohens*a  

* Corresponding authors

a Plataforma de Polimorfisme i Calorimetria, Centres Científics i Tecnològics, Universitat de Barcelona, Barcelona, Spain
E-mail: cris@ccit.ub.edu, rafel@ccit.ub.edu
Fax: +34 934037206
Tel: +34 934034656

b Unitat de Difracció de Raigs X, Centres Científics i Tecnològics, Universitat de Barcelona, Barcelona, Spain

c Urquima S.A., Uriach Group, Arnau de Vilanova 22-42, Sant Fost de Campsentelles, Barcelona, Spain

Abstract

A new kinetically stable polymorph of Vorinostat has been discovered as a result of a polymorph screening, however an impurity is always formed in its preparation by crystallization. The interaction of Vorinostat with ammonia yields a new cocrystal which transforms easily through thermal desorption into the new polymorph with a high degree of purity.

Graphical abstract: A cocrystal is the key intermediates for the production of a new polymorph of Vorinostat

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CE05799E
Article type
Communication
Submitted
27 Jun 2011
Accepted
09 Nov 2011
First published
21 Nov 2011

CrystEngComm, 2012,14, 362-365

Permissions

Request permissions

A cocrystal is the key intermediates for the production of a new polymorph of Vorinostat

C. Puigjaner, R. Barbas, A. Portell, I. Valverde, X. Vila, X. Alcobé, M. Font-Bardia and R. Prohens, CrystEngComm, 2012, 14, 362 DOI: 10.1039/C1CE05799E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements