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We report the formation of left- (M-helix) and right-handed (P-helix) nanoassemblies of a porphyrin–diaminopurine conjugate (Por–DAP) templated by a single stranded oligodeoxythymidine (dT40) via directional hydrogen bonding. The supramolecular helicity can be controlled by the ionic strength, Por–DAP:dT40 ratio, and annealing rate.
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