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Issue 7, 2013
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The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair

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Abstract

The spore photoproduct lyase is a radical SAM enzyme, which repairs 5-(α-thyminyl)-5,6-dihydrothymidine. Here we show that the enzyme establishes a complex radical transfer cascade and creates a cysteine and a tyrosyl radical dyade to establish repair. This allows the enzyme to solve topological and energetic problems associated with the radical based repair reaction.

Graphical abstract: The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair

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Publication details

The article was received on 24 Oct 2012, accepted on 27 Nov 2012 and first published on 28 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37735G
Citation: Chem. Commun., 2013,49, 722-724
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    The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair

    A. C. Kneuttinger, K. Heil, G. Kashiwazaki and T. Carell, Chem. Commun., 2013, 49, 722
    DOI: 10.1039/C2CC37735G

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