Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 39, 2013
Previous Article Next Article

Artificial repressors for controlling gene expression in bacteria

Author affiliations

Abstract

Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon.

Graphical abstract: Artificial repressors for controlling gene expression in bacteria

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 29 Sep 2012, accepted on 16 Nov 2012 and first published on 19 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37107C
Citation: Chem. Commun., 2013,49, 4325-4327
  •   Request permissions

    Artificial repressors for controlling gene expression in bacteria

    M. C. Politz, M. F. Copeland and B. F. Pfleger, Chem. Commun., 2013, 49, 4325
    DOI: 10.1039/C2CC37107C

Search articles by author