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Issue 39, 2013
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Artificial repressors for controlling gene expression in bacteria

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Abstract

Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon.

Graphical abstract: Artificial repressors for controlling gene expression in bacteria

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Publication details

The article was received on 29 Sep 2012, accepted on 16 Nov 2012 and first published on 19 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37107C
Citation: Chem. Commun., 2013,49, 4325-4327
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    Artificial repressors for controlling gene expression in bacteria

    M. C. Politz, M. F. Copeland and B. F. Pfleger, Chem. Commun., 2013, 49, 4325
    DOI: 10.1039/C2CC37107C

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