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Issue 89, 2012
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Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides

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Abstract

A novel and efficient double-carbonylation of indoles with primary or secondary amines to yield indole-3-α-ketoamides has been developed and bioactive molecules could be one-pot synthesized using the current methodology, which could also be selectively switched to mono-carbonylation to afford indole-3-amides only by a slight modification of reaction conditions.

Graphical abstract: Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides

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Publication details

The article was received on 31 Aug 2012, accepted on 23 Sep 2012 and first published on 25 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC36341K
Citation: Chem. Commun., 2012,48, 11023-11025
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    Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides

    Q. Xing, L. Shi, R. Lang, C. Xia and F. Li, Chem. Commun., 2012, 48, 11023
    DOI: 10.1039/C2CC36341K

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