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Issue 85, 2012
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Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

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Abstract

A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial antibiotics myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.

Graphical abstract: Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

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Publication details

The article was received on 07 Aug 2012, accepted on 05 Sep 2012 and first published on 06 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35721F
Citation: Chem. Commun., 2012,48, 10508-10510
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    Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

    A. Colon, T. J. Hoffman, J. Gebauer, J. Dash, J. H. Rigby, S. Arseniyadis and J. Cossy, Chem. Commun., 2012, 48, 10508
    DOI: 10.1039/C2CC35721F

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