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Issue 85, 2012
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Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process

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Abstract

The non-enzymatic kinetic resolution of diversely substituted primary propargylic amines is reported featuring a highly selective acetyl transfer using (1S,2S)-1 in conjunction with AliquatTM 336, affording the corresponding enantio-enriched N-acetylated propargylic amines with unprecedented levels of selectivity (s-factors of up to 193 at 50% conversion).

Graphical abstract: Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process

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Publication details

The article was received on 07 Aug 2012, accepted on 05 Sep 2012 and first published on 06 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35719D
Citation: Chem. Commun., 2012,48, 10511-10513
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    Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process

    A. Kolleth, S. Christoph, S. Arseniyadis and J. Cossy, Chem. Commun., 2012, 48, 10511
    DOI: 10.1039/C2CC35719D

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