Issue 87, 2012
From the journal:

Chemical Communications

Picomolar level profiling of the methylation status of the p53 tumor suppressor gene by a label-free electrochemical biosensor†

Po Wang,ab   Hai Wu,a   Zong Dai*a  and  Xiaoyong Zou*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: ceszxy@mail.sysu.edu.cn, daizong@mail.sysu.edu.cn
Fax: +86 20 84112245
Tel: +86 20 84114919

b School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China
E-mail: wangpo@mail.ahnu.edu.cn
Fax: +86 516 83536977
Tel: +86 516 83403165

Abstract

An efficient electrochemical approach is developed for ultrasensitive profiling of the methylation status of the p53 tumor suppressor gene based on a label-free biosensor in combination with bisulfite conversion.

Graphical abstract: Picomolar level profiling of the methylation status of the p53 tumor suppressor gene by a label-free electrochemical biosensor

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Article information

DOI
https://doi.org/10.1039/C2CC35615E
Article type
Communication
Submitted
02 Aug 2012
Accepted
12 Sep 2012
First published
13 Sep 2012

Chem. Commun., 2012,48, 10754-10756

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Picomolar level profiling of the methylation status of the p53 tumor suppressor gene by a label-free electrochemical biosensor

P. Wang, H. Wu, Z. Dai and X. Zou, Chem. Commun., 2012, 48, 10754 DOI: 10.1039/C2CC35615E

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