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Issue 92, 2012
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An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF–GPIbα interaction

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Abstract

An integrated approach comprising STD NMR screening, pharmacophore based analogue selection and a bioassay is presented for the discovery of a stabilizer of the clinically relevant VWF–GPIbα proteinprotein interaction.

Graphical abstract: An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF–GPIbα interaction

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Publication details

The article was received on 21 Jul 2012, accepted on 01 Oct 2012 and first published on 16 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC35269A
Citation: Chem. Commun., 2012,48, 11349-11351
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    An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF–GPIbα interaction

    R. A. Jose, A. Voet, K. Broos, A. J. Jakobi, G. Bruylants, B. Egle, K. Y. J. Zhang, M. De Maeyer, H. Deckmyn and W. M. De Borggraeve, Chem. Commun., 2012, 48, 11349
    DOI: 10.1039/C2CC35269A

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