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Issue 72, 2012
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Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy

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Abstract

C-di-GMP regulates important processes involved in biofilm formation and virulence factors production in several bacteria. Herein we report a simple fluorescent strategy that allows for the detection of c-di-GMP (as low as 320 nM) using a Vc2 class I riboswitch domain as the sensing region and spinach as the fluorescent reporting module.

Graphical abstract: Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy

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Publication details

The article was received on 19 Jun 2012, accepted on 19 Jul 2012 and first published on 20 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC34379G
Citation: Chem. Commun., 2012,48, 9059-9061
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    Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy

    S. Nakayama, Y. Luo, J. Zhou, T. K. Dayie and H. O. Sintim, Chem. Commun., 2012, 48, 9059
    DOI: 10.1039/C2CC34379G

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