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Issue 80, 2012
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Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX

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Abstract

Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.

Graphical abstract: Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX

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Publication details

The article was received on 13 Jun 2012, accepted on 19 Aug 2012 and first published on 31 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34217K
Citation: Chem. Commun., 2012,48, 10043-10045
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    Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX

    B. Waybrant, T. R. Pearce, P. Wang, S. Sreevatsan and E. Kokkoli, Chem. Commun., 2012, 48, 10043
    DOI: 10.1039/C2CC34217K

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