Issue 65, 2012
From the journal:

Chemical Communications

Preparation of functional benzofurans and indolesvia chemoselective intramolecular Wittig reactions†

Yu-Ting Lee,‡a   Yeong-Jiunn Jang,‡a   Siang-en Syu,a   Shu-Chi Chou,a   Chia-Jui Leea  and  Wenwei Lin*a  

* Corresponding authors

a Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, R.O.C
E-mail: wenweilin@ntnu.edu.tw
Fax: +886 229324249

Abstract

A general preparation of new types of benzofurans, benzothiophenes and indoles is realized via chemoselective intramolecular Wittig reactions with the corresponding ester, thioester and amide functionalities using in situ formed phosphorus ylides as key intermediates. The reaction conditions are very mild, and numerous Michael acceptors and commercially available acid chlorides can be applied very efficiently in a one-step procedure.

Graphical abstract: Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions

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Article information

DOI
https://doi.org/10.1039/C2CC33972B
Article type
Communication
Submitted
03 Jun 2012
Accepted
22 Jun 2012
First published
25 Jun 2012

Chem. Commun., 2012,48, 8135-8137

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Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions

Y. Lee, Y. Jang, S. Syu, S. Chou, C. Lee and W. Lin, Chem. Commun., 2012, 48, 8135 DOI: 10.1039/C2CC33972B

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