Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites

Xuan Xu; Wei Wei; Minghe Huang; Li Yao; Songqin Liu

doi:10.1039/C2CC33575A

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Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites†

Xuan Xu,^a Wei Wei,^a Minghe Huang,^a Li Yao^a and Songqin Liu*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Southeast University Jiangning, Nanjing 211189, People's Republic of China
E-mail: liusq@seu.edu.cn
Fax: +86-25-52090618
Tel: +86-25-52090613

Abstract

We describe herein an electrochemically driven drug metabolism strategy based on nanocomposites that integrate cyt P450 2C9 (CYP2C9) isozyme microsomes with cyt P450 reductase (CPR), indium tin oxide (ITO) nanoparticles and chitosan (CS). This novel bioelectronic system enables monitoring of the drug metabolism and enzyme inhibition.

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Article information

DOI: https://doi.org/10.1039/C2CC33575A
Article type: Communication
Submitted: 17 May 2012
Accepted: 09 Jun 2012
First published: 13 Jun 2012

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Chem. Commun., 2012,48, 7802-7804

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Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites

X. Xu, W. Wei, M. Huang, L. Yao and S. Liu, Chem. Commun., 2012, 48, 7802 DOI: 10.1039/C2CC33575A

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Chemical Communications

Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites†

Abstract

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Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites

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